Optical Fiber Biosensors for Protein Detection: A Review

Proteins play an important role in organisms. The fast and high-accuracy detection of proteins is demanded various fields, such as healthcare, food safty, biosecurity, especially the background globally raging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Optical fiber sensors have great potential for protein due to excellent characteristics high sensitivity, miniaturization, capability remote monitoring. Over past decades, a large number structures been investigated proposed. This paper begins with overview different sensing according fundamental mechanisms. classified into four sections, including intensity-modulation, phase-modulation, scattering, fluorescence. In each section, we reviewed recent advances compared their performance, sensitivity limit detection. And then analyzed advantages disadvantages kinds biosensors. Finally, concludes challenges faced possible future development optical biosensors further study.